Porcine pituitary dynorphin: complete amino acid sequence of the biologically active heptadecapeptide.
نویسندگان
چکیده
The full primary structure of the very potent opioid peptide dynorphin, from porcine pituitary, has been determined. It is (H)Tyr-Gly-Gly-Phe-Leu-Arg-Arg-Ile-Arg-Pro-Lys-Leu-Lys-Trp-Asp-Asn-Gln(OH). The synthetic peptide with this sequence behaves identically to natural dynorphin in a number of ways, and it has the same potency in the guinea pig ileum myenteric plexus--longitudinal muscle bioassay. The potency is accounted for by the first 13 residues.
منابع مشابه
Isolation and amino acid sequence analysis of a 4,000-dalton dynorphin from porcine pituitary.
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ورودعنوان ژورنال:
- Proceedings of the National Academy of Sciences of the United States of America
دوره 78 11 شماره
صفحات -
تاریخ انتشار 1981